40,000 fMRI studies to throw away!

A research team recently revealed what they called a Cluster failure.

Most functional MRI studies conclusions may be erroneous because of their statistical basis. Widely used clustering inference techniques are actually pretty bad at properly inferring clusters due to “spatial autocorrelation functions that do not follow the assumed Gaussian shape”.

It means that “most common software packages for fMRI analysis (SPM, FSL, AFNI) can result in false-positive rates of up to 70%”… suggesting that some results were so inaccurate they could indicate brain activity that does not exist at all!. What is interesting is that neuroscientists are interpreting what they’re told by the statistical software rather than images.

These findings speak to the need of validating the statistical methods being used in the field of neuroimaging.

Therefore, 15 years of research on brain functioning could be invalidated!

But the issue is not limited to research but also extends to clinical use that is pretty worrying.


Image credits: fMRI by OpenStax from the Textbook OpenStax Anatomy and Physiology Published May 18, 2016

Your brain does process information but it is not a computer

I recently came across an article pretending that your brain “does not process information, retrieve knowledge or store memories” and cannot be viewed as a computer.

I personally think that this assertion is fundamentally wrong regarding the information processing.

The computer metaphor is still a valid one

First, I’d like to show you that the computer metaphor couldn’t be discarded so easily.

Of course our brain is not a computer. It is embodied and cannot be considered as an autonomous system.

Exercise Plays Vital Role Maintaining Brain Health, by a health blog

Credits: Exercise Plays Vital Role Maintaining Brain Health, by a health blog

An embodied system…

“Many features of cognition are embodied in that they are deeply dependent upon characteristics of the physical body of an agent” – RA Wilson and L Foglia, Embodied Cognition in The Stanford Encyclopedia of Philosophy

A downloaded brain, if it were possible, would probably not be able to function without a body having human-like sensors and effectors… since a lot of brain activity is dedicated to monitoring sensory inputs, regulating and interacting with the environment.

A system which is itself made up of of multiple systems

Rather than, the brain should be considered as multiples systems that interact together as a whole. Each of them is specialized and is able to communicate with others through different means. The basic elements of those systems are able to transmit signals at different speed, through different pathways: electrical signaling, chemical signaling (neurohormone)… even by using important diffuse systems (glia and immune system).

A limited metaphor…

To put in a nutshell,

“Humans, along with other organisms with brains, differ from computers because they are driven by emotions and motivations. The brain is much too hot and wet to be represented by a computer. The brain is electrical, but it is also driven by fluids (blood) and chemicals (hormones and neurotransmitters). Most importantly, the brain is part of a body which it drives to action, and research from an embodiment perspective also shows that the whole body (not just the brain) affects emotion, motivation, and other psychological processes.”

So what is the adequate metaphor?

Eddie Harmon-Jones, Ph.D., Professor of Psychology at Texas A&M University suggested that

“So, how can we replace the computer metaphor with a metaphor that more accurately represents the brain of an emotion-driven, motivated organism such as a human? I like the metaphor of a car.

A car may have a computer on board, and may be able to process information. But it is driven by fluids (gasoline, oil, etc.). It is both electrical and mechanical, and it can move.”

Renault Scénic Front Cut by Sovxx

Credits: Renault Scénic Front Cut by  Sovxx

Despite the fact that computers can be so complex using most recent advances (for instance VLSI or, simply supercomputers), the car metaphor is far more comprehensible.

We should also consider that computers have no significance if not considered through human perspective. On the contrary, all beings those have a brain exists by themselves.

But a useful metaphor

The metaphor of a brain as a computer helped scientists to gain a better understanding of our brain functioning. No more, no less. Just like both past metaphors of the brain and current ones.

Cognitivism (top down approach), connectionism (bottom up approach) and embodied cognition all succeed at explaining or modeling some aspects of our cognition. In neuroscience, several approaches contribute to explain the neural substrate functioning.

The working memory model , as well as the second revolution in linguistics, etc. were all useful for gaining a better knowledge. A knowledge that is helpful to evaluate individual’s cognitive aspects, model functions and, somehow, understand how the brain works.

These theories are still useful for natural language processing, cognitive remediation, and so on. We haven’t discarded Newtonian theory when Einstein published his general relativity. So is the computer metaphor.

The metaphor is helpful to explore the brain and to exploit its properties but it is not necessarily the ultimate metaphor. Nobody knows what the future has in store…

The brain process information

The brain is not able to recall a detailed picture you saw thousands times (a bank note for instance). That does not mean that it doesn’t store information.

As far as we know the brain stores information using synaptic plasticity (1, 2), i.e. connectivity changes, and brain network topology. The information is scattered through the brain and can be unlearned or mixed with new pieces of information.

Neurons network

What we exactly store is still on debate but it is synthetized and segmented information.

Actually, our brain does process information:

“Information is what is conveyed or represented by a particular arrangement or sequence of things” – Oxford dictionary

Which is exactly what the brain does.

To go further in this explanation:

“Information is an abstract concept. There is a temptation to think of information as fully representable by the bits used in a digital computer. However with signals, the timing of the signal makes a difference. When precisely a signal arrives at a neuron carries information about what the signal means, and there is increasing evidence that the relative timing among neural signals carries information as well. The brain accomplishes information processing using signal processing, but there is more going on than the phrase “information processing” alone would suggest. […]All signal processing is carried out by the spontaneous “random” interactions of molecular collisions, which are loosely guided by the continuously hierarchical structural form of the brain.” – Paul King, Computational Neuroscientist, Data Scientist, Technology Entrepreneur

What is your opinion on the question?




Women and men do have the same brain


I often hear that “boys and girls doesn’t have the same brain”. In fact, it is not true.


In a recent study, the connectome “showed few differences in connectivity up to the age of 13, but became more differentiated in 14- to 17-year-olds” between women and men, explaining some observable general differences. Moreover, it does mean that the observable difference can neither be generalized to all women and men nor imputed to a biological determinism. In other words you can meet less than 5 girls out of 10 who have a “man’s brain” and less than 5 men out of 10 who have a “woman’s brain” (supposing that these typical brains exist…), these people are normal and not infrequent… and the mean difference is not necessarily due to a genetic or hormonal determinism.

Talking in my capacity as graduate in cognitive science and former master’s student in neuroscience, I can claim that the brain is mainly a social construct.

The brain is a social construct

social interaction

The first argument is that, like many scientists have proven, the biological sex should not be seen as a dichotomy but rather as a continuum. If typical women and men existed by essence then they would both have a functionally distinct brain. Fortunately, each cognitive functions can range between two extremes that are not determined by the biological sex.

For the second argument I can confirm that there is no anatomical difference between foetal brains. In the adulthood, the structural scheme of the brain is the same except for control structures of physiological functions and reproduction. You may find more differences between two male brains than between a female and a male brain (exactly like the genomic differences that are likely to be as numerous between two white people as between two randomly selected black and white people).

The third argument is: the only observable differences (that are statistically significant) are a social construct.

Remember the citation about the connectome? The difference appears by 14-17. It doesn’t seem to support the idea that the brains are wired differently from start.

So far, I have never seen an article claiming to prove a chemical or structural difference which doesn’t suffer from a bias. The only sexual differences are actually gender difference, socially induced in every species (read here and here)… which affects the way we behave. Humans are able to bypass genetic and hormonal determinisms.

If you make an effort, thanks to neural plasticity, you can unmake a learned difference. Think about it the next time you will consider a behavior as a natural one…